Omics Analysis
Molecular Pathways/AOPs
Monitoring NMs – Organisms Interactions
The NanoSolveIT platform offers multiple tools for analysis of gene expression, transcriptomics, and other large-scale datasets, as well as access to molecular pathway and AOP databases.
Available Services
eUTOPIA – Preprocessing and analysis of omics data
Graphically accessible guided workflow for preprocessing and analysis of omics data. Supports Agilent 2-color, Agilent 1-color, Affymetrix, and Illumina methylation microarray platforms.
FunMappOne – Visualisation of molecular biology experiments
A user-friendly graphical interface that allows to visualise and summarise the functional annotations of one or multiple molecular biology experiments at once.
Adverse Outcome Pathway Wiki data access with SPARQL queries
The service contains a SPARQL endpoint that is loaded with RDF of the Adverse Outcome Pathway (AOP)-Wiki database (https://aopwiki.org/), based on the quarterly XML dumps that are provided. On top of that, a SNORQL User Interface facilitates the exploration of data and provides example queries. The AOP-Wiki serves as the primary repository of qualitative information for AOPs and is a central component in the AOP development effort coordinated by the Organisation for Economic Co-operation and Development (OECD). The database contains AOP which are described in terms of key events (KEs). An AOP is initiated by a stressor (e.g. a chemical) that causes a Molecular Initiating Event, which is followed by KEs (measurable, essential steps) along a pathway towards an adverse outcome for an organism or population. KEs are connected through Key Event Relationships (KERs), which capture the evidence supporting the AOP in a structured way. The AOP-Wiki website provides access to the AOP information via a web interface to look up AOPs, KEs, KERs, and stressors.
Molecular Pathway database access with SPARQL queries
The service contains a SPARQL endpoint that is loaded with RDF of the WikiPathways database (https://wikipathways.org/), and is updated each month. On top of that, a SNORQL User Interface facilitates the exploration of data and provides example queries. WikiPathways is a molecular pathway database to capture molecular descriptors, interactions and processes, and allows data analyses.